Decrease in CD93 (C1qRp) Expression in a Human Monocyte-Like Cell Line (U937) Treated with Various Apoptosis-Inducing Chemical Substances

Silymarin inhibits Toll-like receptor 8 gene expression and apoptosis in Ramos cancer cell line

Objective: Silymarin is a herbal extract containing flavonolignans, and it has inhibitory effects against the growth of different cancer cell lines by inducing apoptosis. Toll-like receptors are suggested as a novel and attractive target to treat cancer. The current study aimed at examining the mechanism of silymarin-induced apoptosis in Ramos cells and investigating its effect...

Parthenolide Induces Apoptosis in Committed Progenitor AML Cell line U937 via Reduction in Osteopontin

Background: Interfering with cell proliferation and survival is a critical role for antineoplastic drugs leading to cell death through induction of apoptosis. Alternative treatments with herbal extracts offer insights into acute myeloid leukemia (AML) therapy. Parthenolide (PTL), an extract from feverfew, induces apoptosis in primary human leukemia stem cells (LSCs) and bulk leukemic cell popul...

Evaluation of Growth Inhibitory and Apoptosis Inducing Activity of Human Calprotectin on the Human Gastric Cell Line (AGS)

Background: Calprotectin is cytotoxic agent that its anti-tumor effects are governed through suppression of topoisomerase II a key enzyme in apoptosis. In previous studies, cytotoxicity and apoptotic effects of calprotectin are shown on different cancer cell lines, but not human gastric cancer cell lines. In the present study, cytotoxicity and apoptotic effects of calprotectin on human gastric ...

monocyte-like cell line

The complement fragment C5a and its des-Arg74 derivative, C5a des Arg, are potent mediators of leucocyte chemotaxis and are thought to play an important role in the accumulation of leucocytes at sites of inflammation. Although specific receptors for C5a have been demonstrated on murine macrophages (Chenoweth et al., 1982) and human monocytes (Chenoweth & Goodman, 1983; Marder et al., 1985), mos...

Regulated Cell Death: Apoptosis and Necroptosis in U937 Cell Line